Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa

被引:143
作者
Gerrard, SR
Li, L
Barrett, AD
Nichol, ST
机构
[1] Ctr Dis Control & Prevent, Special Pathogens Branch, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA
[2] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48103 USA
[3] Univ Texas, Ctr Biodef & Emerging Infect Dis, Med Branch, Galveston, TX 77555 USA
[4] Univ Texas, Dept Pathol, Med Branch, Galveston, TX 77555 USA
关键词
D O I
10.1128/JVI.78.16.8922-8926.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Two isolates of a virus of the genus Orthobunyavirus (family Bunyaviridae) were obtained from hemorrhagic fever cases during a large disease outbreak in East Africa in 1997 and 1998. Sequence analysis of regions of the three genomic RNA segments of the virus (provisionally referred to as Garissa virus) suggested that it was a genetic reassortant virus with S and L segments derived from Bunyamwera virus but an M segment from an unidentified virus of the genus Orthobunyavirus. While high genetic diversity (52%) was revealed by analysis of virus M segment nucleotide sequences obtained from 21 members of the genus Orthobunyavirus, the Garissa and Ngari virus M segments were almost identical. Surprisingly, the Ngari virus L and S segments showed high sequence identity with those of Bunyamwera virus, showing that Garissa virus is an isolate of Ngari virus, which in turn is a Bunyamwera virus reassortant. Ngari virus should be considered when investigating hemorrhagic fever outbreaks throughout sub-Saharan Africa.
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页码:8922 / 8926
页数:5
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