Identification of inhibitors for UDP-galactopyranose mutase

被引：86

作者：

Soltero-Higgin, M

Carlson, EE

Phillips, JH

Kiessling, LL

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 34期

关键词：

D O I：

10.1021/ja048017v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The flavoenzyme uridine 5′-diphosphate (UDP)-galactopyranose mutase (UGM) plays a key role in the cell wall biosynthesis of many pathogens, including Mycobacterium tuberculosis. Using a synthetic fluorescent ligand, we screened 16000 compounds in a fluorescence polarization assay. Effective inhibitors of UGM were identified. Copyright © 2004 American Chemical Society.

引用

页码：10532 / 10533

页数：2

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