Type-IV Indian swine HEV infects rhesus monkeys

被引：61

作者：

Arankalle, V. A. ^{[1
]}

Chobe, L. P. ^{[1
]}

Chadha, M. S. ^{[1
]}

机构：

[1] Natl Inst Virol, Hepatitis Div, Pune 411001, Maharashtra, India

来源：

JOURNAL OF VIRAL HEPATITIS | 2006年 / 13卷 / 11期

关键词：

hepatitis E; rhesus monkeys; sequence comparisons; transmission;

D O I：

10.1111/j.1365-2893.2006.00759.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In contrast to countries reporting zoonotic spread of hepatitis E virus (HEV), distinct genotypes circulate in humans (genotype 1) and pigs (genotype 4) from India indicating rarity of such spread. Pigs were refractory to human HEV. As rhesus is an excellent animal model for human HEV, an attempt was made to infect rhesus monkeys with swine HEV. Experimental infection of both the rhesus monkeys with swine-HEV as evidenced by seroconversion to anti-HEV antibodies and presence of viraemia suggests possibility of human infections or differential susceptibility. Comparison of Open Reading Frame-2 and hypervariable regions of HEV genomes showed identity of swine and monkey-derived HEV.

引用

页码：742 / 745

页数：4

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