An Amino Acid Shuffle Activates mTORC1

被引：52

作者：

Cohen, Adiel ^{[1
]}

Hall, Michael N. ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

CELL | 2009年 / 136卷 / 03期

关键词：

RAG GTPASES;

D O I：

10.1016/j.cell.2009.01.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The mammalian target of rapamycin complex 1 (mTORC1), which promotes cell growth, is regulated by specific nutrients such as the amino acid leucine. In this issue, Nicklin et al. (2009) describe a mechanism by which glutamine facilitates the uptake of leucine, leading to mTORC1 activation.

引用

收藏

页码：399 / 401

页数：3

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