Virulent Strain of Hepatitis E Virus Genotype 3, Japan

被引:41
作者
Takahashi, Kazuaki [1 ]
Okamoto, Hiroaki [2 ]
Abe, Natsumi
Kawakami, Manri [3 ]
Matsuda, Hiroyuki [4 ]
Mochida, Satoshi [5 ]
Sakugawa, Hiroshi
Suginoshita, Yoshiki [6 ]
Watanabe, Seishiro
Yamamoto, Kazuhide [7 ]
Miyakawa, Yuzo [8 ]
Mishiro, Shunji
机构
[1] Toshiba Gen Hosp, Dept Med Sci, Shinagawa Ku, Tokyo 1408522, Japan
[2] Jichi Med Univ, Sch Med, Mibu, Tochigi, Japan
[3] Kurashiki Med Ctr, Okayama, Japan
[4] Matsuda Naika Clin, Tottori, Japan
[5] Saitama Med Univ, Saitama, Japan
[6] Kyoto Univ, Grad Sch Med, Kyoto, Japan
[7] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan
[8] Miyakawa Mem Res Fdn, Tokyo, Japan
关键词
GENOME; TRANSMISSION; PREVALENCE; ANTIBODIES; SEQUENCES; FULMINANT; DEER;
D O I
10.3201/eid1505.081100
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Hepatitis E virus (HEV) genotype 3, which usually causes asymptomatic infection in Japan, induced severe hepatitis in 8 patients. To better understand genetic features of HEV associated with increased virulence, we determined the complete or near-complete nucleotide sequences of HEV from these 8 patients and from 5 swine infected with genotype 3 strain swJ19. Phylogenetic analysis showed that the isolates from the 8 patients and the 5 swine grouped separately from the other genotype 3 isolates to create a unique cluster, designated JIO. The human JIO-related viruses encoded 18 amino acids different from those of the other HEV genotype 3 strains. One substitution common to almost all human HEV strains in the JIO cluster was located in the helicase domain (V239A) and may be associated with increased virulence. A zoonotic origin of JIO-related viruses is suspected because the isolates from the 5 swine also possessed the signature V239A substitution in helicase.
引用
收藏
页码:704 / 709
页数:6
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