The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes

被引：78

作者：

Cording, S. ^{[1
]}

Wahl, B. ^{[2
]}

Kulkarni, D. ^{[1
]}

Chopra, H. ^{[2
]}

Pezoldt, J. ^{[1
]}

Buettner, M. ^{[3
]}

Dummer, A. ^{[1
]}

Hadis, U. ^{[2
]}

Heimesaat, M. ^{[4
]}

Bereswill, S. ^{[4
]}

Falk, C. ^{[5
]}

Bode, U. ^{[3
,6
,7
]}

Hamann, A. ^{[5
]}

Fleissner, D. ^{[1
]}

Huehn, J. ^{[1
]}

Pabst, O. ^{[2
]}

机构：

[1] Helmholtz Ctr Infect Res, Braunschweig, Germany

[2] Hannover Med Sch, Inst Immunol, Hannover, Germany

[3] Hannover Med Sch, Inst Funct & Appl Anat, Hannover, Germany

[4] Charite, Inst Microbiol & Hyg, D-13353 Berlin, Germany

[5] Hannover Med Sch, IFB Tx, Hannover, Germany

[6] German Rheumatism Res Ctr Berlin, Berlin, Germany

[7] Charite, D-13353 Berlin, Germany

来源：

MUCOSAL IMMUNOLOGY | 2014年 / 7卷 / 02期

关键词：

REGULATORY T-CELLS; CD103(+) DENDRITIC CELLS; RETINOIC-ACID; INTEGRIN ALPHA-V-BETA-8; ORAL TOLERANCE; IN-VIVO; GENERATION; FOXP3; BETA; EXPRESSION;

D O I：

10.1038/mi.2013.54

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

De novo induction of Foxp3(+) regulatory T cells (Tregs) is particularly efficient in gut-draining mesenteric and celiac lymph nodes (mLN and celLN). Here we used LN transplantations to dissect the contribution of stromal cells and environmental factors to the high Treg-inducing capacity of these LN. After transplantation into the popliteal fossa, mLN and celLN retained their high Treg-inducing capacity, whereas transplantation of skin-draining LN into the gut mesenteries did not enable efficient Treg induction. However, de novo Treg induction was abolished in the absence of dendritic cells (DC), indicating that this process depends on synergistic contributions of stromal and DC. Stromal cells themselves were influenced by environmental signals as mLN grafts taken from germ-free donors and celLN grafts taken from vitamin A-deficient donors did not show any superior Treg-inducing capacity. Collectively, our observations reveal a hitherto unrecognized role of LN stromal cells for the de novo induction of Foxp3(+) Tregs.

引用

页码：359 / 368

页数：10

共 34 条

[1]

Stromal cells confer lymph node-specific properties by shaping a unique microenvironment influencing local immune responses [J].