A new approach for direct in vivo dissolution studies of poorly soluble drugs

被引：22

作者：

Bonlokke, L

Christensen, FN

Knutson, L

Kristensen, HG

Lennernas, H

机构：

[1] UNIV UPPSALA,DEPT PHARM,DIV BIOPHARMACEUT & PHARMACOKINET,S-75105 UPPSALA,SWEDEN

[2] ROYAL DANISH SCH PHARM,DEPT PHARMACEUT,DK-2100 COPENHAGEN,DENMARK

[3] UNIV UPPSALA,DEPT SURG,S-75105 UPPSALA,SWEDEN

来源：

PHARMACEUTICAL RESEARCH | 1997年 / 14卷 / 10期

关键词：

in vivo dissolution; Loc-I-Gut; Carbamazepine; sparingly soluble drugs; intestinal perfusion;

D O I：

10.1023/A:1012149511768

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：1490 / 1492

页数：3

共 15 条

[1] A THEORETICAL BASIS FOR A BIOPHARMACEUTIC DRUG CLASSIFICATION - THE CORRELATION OF IN-VITRO DRUG PRODUCT DISSOLUTION AND IN-VIVO BIOAVAILABILITY [J].

AMIDON, GL ;

LENNERNAS, H ;

SHAH, VP ;

CRISON, JR .

PHARMACEUTICAL RESEARCH, 1995, 12 (03) :413-420

[2]

Chang Eugene B., 1994, P2027

[3]

FREY HH, 1980, ARCH INT PHARMACOD T, V243, P180

[4] GASTROINTESTINAL BIOAVAILABILITY - DETERMINATION OF INVIVO RELEASE PROFILES OF SOLID ORAL DOSAGE FORMS BY DECONVOLUTION [J].

GILLESPIE, WR ;

VENGPEDERSEN, P .

BIOPHARMACEUTICS & DRUG DISPOSITION, 1985, 6 (03) :351-355

[5] PHYSICAL-CHEMICAL BEHAVIOR OF DIETARY AND BILIARY LIPIDS DURING INTESTINAL DIGESTION AND ABSORPTION .2. PHASE-ANALYSIS AND AGGREGATION STATES OF LUMINAL LIPIDS DURING DUODENAL FAT DIGESTION IN HEALTHY ADULT HUMAN-BEINGS [J].

HERNELL, O ;

STAGGERS, JE ;

CAREY, MC .

BIOCHEMISTRY, 1990, 29 (08) :2041-2056

[6]

KERLIN P, 1982, GASTROENTEROLOGY, V82, P701

[7]

KNUTSON L, 1989, AM J GASTROENTEROL, V84, P1278

[8] REGIONAL JEJUNAL PERFUSION, A NEW INVIVO APPROACH TO STUDY ORAL-DRUG ABSORPTION IN MAN [J].

LENNERNAS, H ;

AHRENSTEDT, O ;

HALLGREN, R ;

KNUTSON, L ;

RYDE, M ;

PAALZOW, LK .

PHARMACEUTICAL RESEARCH, 1992, 9 (10) :1243-1251

[9]

LEVY RH, 1975, CLIN PHARMACOL THER, V17, P657

[10] Jejunal permeability and hepatic extraction of fluvastatin in humans [J].

Lindahl, A ;

Sandstrom, R ;

Ungell, AL ;

Abrahamsson, B ;

Knutson, TW ;

Knutson, L ;

Lennernas, H .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1996, 60 (05) :493-503

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