A potentially deleterious role of IGFBP-2 on bone density in aging men and women

被引：57

作者：

Amin, S

Riggs, BL

Atkinson, EJ

Oberg, AL

Melton, LJ

Khosla, S

机构：

[1] Mayo Clin, Div Rheumatol, Coll Med, Dept Internal Med, Rochester, MN 55905 USA

[2] Mayo Clin, Div Metab Endocrinol & Nutr, Coll Med, Dept Internal Med, Rochester, MN 55905 USA

[3] Mayo Clin, Div Biostat, Coll Med, Dept Hlth Sci Res, Rochester, MN 55905 USA

[4] Mayo Clin, Div Epidemiol, Coll Med, Dept Hlth Sci Res, Rochester, MN 55905 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 07期

关键词：

insulin-like growth factors; insulin-like growth factor binding proteins; bone density;

D O I：

10.1359/JBMR.040301

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of the IGFs and IGFBPs on age-related changes in BMD in adult men and women is not well understood. Studying an age-stratified community based sample of 344 men and 276 women, we found higher IGFBP-2 levels to be associated with lower BMD. IGFBP-2, which increases with age in both men and women, was the strongest, most consistent predictor of BMD among the IGF/IGFBPs studied.

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收藏

页码：1075 / 1083

页数：9

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