Glutamic acid decarboxylase message isoforms in human suprachiasmatic nucleus

被引:17
作者
Gao, B
Moore, RY
机构
[1] UNIV PITTSBURGH, CTR NEUROSCI, ALZHEIMERS DIS RES CTR, DEPT NEUROL, PITTSBURGH, PA 15261 USA
[2] UNIV PITTSBURGH, CTR NEUROSCI, ALZHEIMERS DIS RES CTR, DEPT NEUROSCI, PITTSBURGH, PA 15261 USA
[3] UNIV PITTSBURGH, CTR NEURAL BASIS COGNIT, PITTSBURGH, PA 15261 USA
关键词
GABA; GAD(65); GAD(67); in situ hybridization; circadian system; paraventricular nucleus; Alzheimer's disease;
D O I
10.1177/074873049601100209
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The rat suprachiasmatic nucleus (SCN) is comprised of neurons that contain gamma-amino butyric acid (GABA) colocalized with one or more peptides. In the present study, the authors employed in situ hybridization histochemistry to determine whether the human SCN also contains GABA neurons using synthetic oligonucleotide probes complementary to sequences of two isoforms of the GABA-forming enzyme, glutamic acid decarboxylase (GAD), GAD(65), and GAD(67). Most, if not all, SCN neurons appear to express both GAD(65) mRNA and GAD(67) mRNA with the content of GAD(67) greater than GAD(65). Both isoforms also are expressed in some neurons of the anterior hypothalamic area, in small neurons of the paraventricular nucleus but not in the supraoptic nucleus. These data indicate that neurons in the human SCN, Like those in rodents, use GABA as a neurotransmitter.
引用
收藏
页码:172 / 179
页数:8
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