Adenosine A(2A) antagonists with potent anti-cataleptic activity

被引：87

作者：

Shimada, J

Koike, N

Nonaka, H

Shiozaki, S

Yanagawa, K

Kanda, T

Kobayashi, H

Ichimura, M

Nakamura, J

Kase, H

Suzuki, F

机构：

[1] Pharmaceutical Research Institute, Drug Discovery Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Sunto-gun, Shizuoka 411, 1188 Shimotogari, Nagaizumi-cho

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(97)00440-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structure-activity relationships of 8-styrylxanthines for in vivo adenosine A(2A) antagonism were explored. Diethyl substitution both at the 1- and 3-posit;on was found to dramatically potentiate the anti-cataleptic activity. (C) 1997 Elsevier Science Ltd.

引用

页码：2349 / 2352

页数：4

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