Cerebral amyloid angiopathy: An overview

被引：152

作者：

Yamada, M ^{[1
]}

机构：

[1] Kanazawa Univ, Sch Med, Dept Neurol, Kanazawa, Ishikawa 9208640, Japan

来源：

NEUROPATHOLOGY | 2000年 / 20卷 / 01期

关键词：

Alzheimer's disease; amyloid beta protein; cerebral amyloid angiopathy; cerebral hemorrhage; cerebrovascular disorders; cystatin C; dementia;

D O I：

10.1046/j.1440-1789.2000.00268.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral amyloid angiopathy (CAA) is characterized by amyloid deposition in cortical and leptomeningeal vessels. Several cerebrovascular amyloid proteins (amyloid beta-protein (A beta), cystatin C (ACys), prion protein (AScr), transthyretin (ATTR), gelsolin (AGel), and ABri (or A-WD)) have been identified, leading to the classification of several types of CAA. Sporadic CAA of A beta type is commonly found in elderly individuals and patients with Alzheimer's disease. Cerebral amyloid angiopathy is an important cause of cerebrovascular disorders including lobar cerebral hemorrhage, leukoencephalopathy, and small cortical hemorrhage and infarction. We review the clinicopathological and molecular aspects of CAA and discuss the pathogenesis of CAA with future perspectives.

引用

页码：8 / 22

页数：15

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