Trifluoromethyl-substituted indenyl rhodium and iridium complexes are highly selective catalysts for directed hydroboration reactions

被引：36

作者：

Brinkman, JA ^{[1
]}

Nguyen, TT ^{[1
]}

Sowa, JR ^{[1
]}

机构：

[1] Seton Hall Univ, Dept Chem, S Orange, NJ 07079 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 07期

关键词：

D O I：

10.1021/ol005653z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Rhodium and iridium catalysts containing trifluoromethyl-substituted indenyl ligands (Ind'MCod, Ind' = C(9)H(7), (1-CF(3))C(9)H(6), (2-CF(3))C(9)H(6), (1,3-CF(3))(2)C(9)H(5)) have been developed for the directed hydroboration of 4-(benzyloxy)cyclohexene to cis-3-(benzyloxy)cyclohexanol. Compared to unsubstituted complexes, trifluoromethyl substitution yields a 3-10% increase in selectivity which is attributed to the strong electron-withdrawing effect of the trifluoromethyl group. Rhodium complexes give selectivities of 74-84%, and iridium complexes give high levels of selectivity (93-98%).

引用

页码：981 / 983

页数：3

共 17 条

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