Visualizing Vesicular Dopamine Dynamics in Parkinson's Disease

被引：37

作者：

de la Fuente-Fernandez, Raul ^{[1
]}

Sossi, Vesna ^{[2
]}

McCormick, Siobhan ^{[1
]}

Schulzer, Michael ^{[1
]}

Ruth, Thomas J. ^{[3
]}

Stoessl, A. Jon ^{[1
]}

机构：

[1] Univ British Columbia, Pacific Parkinsons Res Ctr, Vancouver, BC V6T 2B5, Canada

[2] Univ British Columbia, Dept Phys & Astron, Vancouver, BC V6T 2B5, Canada

[3] Univ British Columbia, TRIUMF, Vancouver, BC V6T 2B5, Canada

来源：

SYNAPSE | 2009年 / 63卷 / 08期

基金：

加拿大健康研究院;

关键词：

PET; tetrabenazine; VMAT2; MOTOR FLUCTUATIONS; VMAT2; BINDING; MECHANISMS; LEVODOPA;

D O I：

10.1002/syn.20653

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been suggested that dopamine derived from exogenous levodopa may not follow vesicular dynamics in Parkinson's disease (PD). Using a novel PET method based on the sensitivity of [C-11]-dihydrotetrabenazine (DTBZ) binding to changes in vesicular dopamine levels, we show here that striatal [C-11]-DTBZ binding decreases after levodopa administration in advanced PD, likely reflecting an increase in vesicular dopamine levels. Endogenous dopamine and exogenously derived dopamine seem to follow the same vesicular dynamics. Synapse 63:713-716, 2009. (c) 2009 Wiley-Liss, Inc.

引用

页码：713 / 716

页数：4

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