Molecular epidemiology of viral infections - How sequence information helps us understand the evolution and dissemination of viruses

被引：27

作者：

Hungnes, O ^{[1
]}

Jonassen, TO ^{[1
]}

Jonassen, CM ^{[1
]}

Grinde, B ^{[1
]}

机构：

[1] Natl Inst Publ Hlth, Dept Virol, N-0403 Oslo, Norway

来源：

APMIS | 2000年 / 108卷 / 02期

关键词：

virus; epidemiology; molecular analysis; evolution; routes of infection; nucleic acid sequence;

D O I：

10.1034/j.1600-0463.2000.d01-31.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Viruses evolve much faster than cellular organisms. Together with recent advances in nucleic acid sequencing and biocomputing, this allows us to distinguish between related strains of viruses, and to deduce the relationships between viruses from different outbreaks or individual patients. Databases of nucleotide sequences contain a large number of viral sequences with which novel sequences from local outbreaks can be compared. In this way the dissemination of viruses can be followed both locally and globally We here review the biological and technological background to the use of virus nucleic acid sequences in epidemiological studies, and provide examples of how this information can be used to monitor human viruses. Molecular studies are particularly valuable for understanding the dissemination and evolution of viruses. The knowledge obtained is useful in epidemiological reconstructions, in real-time surveillance, and may even enable us to make predictions about the future developments of viral diseases.

引用

页码：81 / 97

页数：17

共 72 条

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