MECHANISMS OF DISEASE Immunologic Aspects of Chronic Obstructive Pulmonary Disease

被引：593

作者：

Cosio, Manuel G. ^{[1
,2
]}

Saetta, Marina ^{[3
]}

Agusti, Alvar ^{[4
,5
]}

机构：

[1] McGill Univ, Royal Victoria Hosp, Resp Div, Montreal, PQ H3A 1A1, Canada

[2] McGill Univ, Meakins Christie Labs, Dept Med, Montreal, PQ H3A 1A1, Canada

[3] Univ Padua, Dept Cardiac Thorac & Vasc Sci, Sect Resp Dis, Padua, Italy

[4] Hosp Univ Son Dureta, Fdn Caubet Cimera, Mallorca, Balearic Isl, Spain

[5] CIBER Enfermedades Resp, Mallorca, Balearic Isl, Spain

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 360卷 / 23期

关键词：

TOLL-LIKE RECEPTORS; T-LYMPHOCYTE RESPONSE; AIR-FLOW OBSTRUCTION; DENDRITIC CELLS; AUTOIMMUNE-DISEASES; INCREASED EXPRESSION; PERIPHERAL AIRWAYS; BRONCHIAL BIOPSIES; TOBACCO SMOKING; LUNG-FUNCTION;

D O I：

10.1056/NEJMra0804752

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review is an account of how pulmonary damage caused by cigarette smoke and other environmental toxins can incite inflammatory and immunologic reactions that culminate in chronic obstructive pulmonary disease (COPD). The authors present evidence that autoimmunity has a role in the development of COPD. Copyright © 2009 Massachusetts Medical Society.

引用

页码：2445 / 2454

页数：10

共 101 条

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ABBAS AK, 2000, CELLULAR MOL IMMUNOL, P291

[2] Hypothesis: Does COPD have an autoimmune component? [J].