The regulatory role of MRP8 (S100A8) and MRP14 (S100A9) in the transendothelial migration of human leukocytes

被引：54

作者：

Kerkhoff, C ^{[1
]}

Eue, I ^{[1
]}

Sorg, C ^{[1
]}

机构：

[1] Inst Expt Dermatol, D-48149 Munster, Germany

来源：

PATHOBIOLOGY | 1999年 / 67卷 / 5-6期

关键词：

adhesion; arachidonic acid; beta; 2; integrins; inflammation; secretion;

D O I：

10.1159/000028098

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The hallmark of developing inflammatory lesions is the excess migration of recruited phagocytes together with the enhanced cell surface expression of adhesion molecules. Recent investigations give evidence that the two myeloid-related proteins MRP8 (S100A8) and MRP14 (S100A9), which are abundant in activated or recruited phagocytes, may have a modulatory role in inflammatory responses. S100A9 displays a regulatory role in the transendothelial migration of human monocytes, and the secreted S100A8/A9 complex may serve as a transport protein to move arachidonic acid to its target cells. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：230 / 232

页数：3

共 12 条

[1]

De Caterina R, 1998, J LIPID RES, V39, P1062

[2]

EUR I, UNPUB REGULATION TRA

[3] Chemotaxins C5a and fMLP induce release of calprotectin (leucocyte L1 protein) from polymorphonuclear cells in vitro [J].