Mitotic chromosome structure and condensation

被引：145

作者：

Belmont, Andrew S. ^{[1
]}

机构：

[1] Univ Illinois, Dept Cell & Dev Biol, Urbana, IL 61802 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2006年 / 18卷 / 06期

关键词：

D O I：

10.1016/j.ceb.2006.09.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitotic chromosome structure has been the cell biology equivalent of a 'riddle, wrapped in a mystery, inside an enigma'. Observations that genetic knockout or knockdown of condensin subunits or topoisomerase II cause only minimal perturbation in overall chromosome condensation, together with analysis of early stages of chromosome condensation and effects produced by histone H1 depletion, suggest a need to reconsider textbook models of mitotic chromosome condensation and organization.

引用

页码：632 / 638

页数：7

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