TWEAK is expressed by glial cells, induces astrocyte proliferation and increases EAE severity

被引：120

作者：

Desplat-Jégo, S

Varriale, S

Creidy, R

Terra, R

Bernard, D

Khrestchatisky, M

Izui, S

Chicheportiche, Y

Boucraut, J

机构：

[1] Univ Mediterranee, IFR Jean Roche, NICN CNRS FRE 2533, F-13916 Marseille 20, France

[2] CMU, Dept Pathol, CH-1211 Geneva, Switzerland

[3] CYGEN, CH-1227 Carouge, Switzerland

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 133卷 / 1-2期

关键词：

TWEAK; cytokines; glial cells; experimental auto-immune encephalomyelitis;

D O I：

10.1016/S0165-5728(02)00368-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TWEAK is a new TNF family member with proinflammatory and proliferative effects on different cell types, mediated by the recently identified Fn14 receptor. TWEAK expression was analyzed on mouse microglial cells and astrocytes. Both cell types express TWEAK mRNA. Astrocytes expressed Fn14 and proliferated in the presence of rTWEAK. TWEAK mRNA is expressed in normal CNS and its steady state level increases in spinal cord during EAE. Finally, EAE severity is enhanced in soluble TWEAK-overexpressing transgenic mice. These results support the contention that TWEAK is involved in CNS inflammation. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：116 / 123

页数：8

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