A reproducible and high-yielding cerium-mediated route to alpha,alpha-difluoro-beta-ketophosphonates.

被引：31

作者：

Blades, K ^{[1
]}

Lequeux, TP ^{[1
]}

Percy, JM ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 30期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4020(97)00673-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The addition of diethyldifluoromethylphosphonate to LDA containing cerium(III) chloride in THF generates an organometallic nucleophile that reacts efficiently with esters and DMF (1,2-addition) affording moderate to good yields of adducts, and extending considerably the range of compounds available containing the difluoromethylenephosphonate group. (C) 1997 Elsevier Science Ltd.

引用

页码：10623 / 10632

页数：10

共 41 条

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