Treatment of severe Evans syndrome with an allogeneic cord blood transplant

被引:42
作者
Raetz, E
Beatty, PG
Adams, RH
机构
[1] UNIV UTAH,SCH MED,DEPT MED,SALT LAKE CITY,UT 84132
[2] UNIV UTAH,SCH MED,DEPT PEDIAT,SALT LAKE CITY,UT 84132
关键词
cord blood transplant; Evans syndrome; autoimmune disease;
D O I
10.1038/sj.bmt.1700907
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Immunosuppressive therapy is commonly used in the management of autoimmune disorders, As marrow-derived lymphocytes appear to play a key role in these diseases, lymphoid ablation followed by replacement with autologous or allogeneic stem cells may be a therapeutic option. We report a 5-year-old boy with severe Evans syndrome which consists of immune thrombocytopenia and Coombs-positive hemolytic anemia. He was rendered into complete remission with marrow ablation followed by rescue with an HLA-identical sibling cord blood transplant. He unexpectedly died 9 months following transplant from acute hepatic failure of unknown etiology.
引用
收藏
页码:427 / 429
页数:3
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