Design and analysis of extruded quadrupolar dielectrophoretic traps

被引:116
作者
Voldman, J [1 ]
Toner, M
Gray, ML
Schmidt, MA
机构
[1] MIT, Dept Genet, Boston, MA 02115 USA
[2] Massachusetts Gen Hosp, Ctr Engn Med, Boston, MA 02114 USA
基金
美国国家科学基金会;
关键词
dielectrophoretic levitation; quadrupolar traps; cell analysis;
D O I
10.1016/S0304-3886(02)00120-1
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
We present the design and experimental analysis of a dielectrophoretic trap composed of four microfabricated gold posts excited in a quadrupolar fashion. Using quantitative modeling tools, we have designed these extruded traps to attain strong holding against flow while being constrained by a set of system parameters. The extruded geometry consists of cylindrical electrodes in a trapezoidal arrangement and substrate-interconnect shunts. The traps can be individually electrically switched, are easily arrayable, and are amenable to batch fabrication. We have verified the predicted performance of the extruded traps by measuring holding of beads against flows and comparing to the model predictions. The results demonstrate that extruded quadrupolar traps exhibit strong particle confinement and that the modeling tools can be used for a priori design of dielectrophoresis-based single-particle traps. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:69 / 90
页数:22
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