The future of antigen-specific immunotherapy of allergy

被引：264

作者：

Valenta, R ^{[1
]}

机构：

[1] Univ Vienna, Sch Med, Vienna Gen Hosp AKH, Mol Immunopathol Grp,Dept Pathophysiol, A-1090 Vienna, Austria

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 06期

基金：

英国医学研究理事会; 奥地利科学基金会;

关键词：

D O I：

10.1038/nri824

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

More than 25% of the population in industrialized countries suffers from immunoglobulin-E-mediated allergies. The antigen-specific immunotherapy that is in use at present involves the administration of allergen extracts to patients with the aim to cure allergic symptoms. However, the risk of therapy-induced side effects limits its broad application. Recent work indicates that the epitope complexity of natural allergen extracts can be recreated using recombinant allergens, and hypoallergenic derivatives of these can be engineered to increase treatment safety. It is proposed that these modified molecules will improve the current practice of specific immunotherapy and form a basis for prophylactic vaccination.

引用

页码：446 / 453

页数：8

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