Electrical coupling and neuronal synchronization in the mammalian brain

被引:581
作者
Bennett, MVL [1 ]
Zukin, RS [1 ]
机构
[1] Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA
关键词
D O I
10.1016/S0896-6273(04)00043-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Certain neurons in the mammalian brain have long been known to be joined by gap junctions, which are the most common type of electrical synapse. More recently, cloning of neuron-specific connexins, increased capability of visualizing cells within brain tissue, labeling of cell types by transgenic methods, and generation of connexin knockouts have spurred a rapid increase in our knowledge of the role of gap junctions in neural activity. This article reviews the many subtleties of transmission mediated by gap junctions and the mechanisms whereby these junctions contribute to synchronous firing.
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页码:495 / 511
页数:17
相关论文
共 159 条
[1]   Functional alterations in gap junction channels formed by mutant forms of connexin 32: evidence for loss of function as a pathogenic mechanism in the X-linked form of Charcot-Marie-Tooth disease [J].
Abrams, CK ;
Freidin, MM ;
Verselis, VK ;
Bennett, MVL ;
Bargiello, TA .
BRAIN RESEARCH, 2001, 900 (01) :9-25
[2]  
Altevogt BM, 2002, J NEUROSCI, V22, P6458
[3]  
Alvarez-Maubecin V, 2000, J NEUROSCI, V20, P4091
[4]   The spatial dimensions of electrically coupled networks of interneurons in the neocortex [J].
Amitai, Y ;
Gibson, JR ;
Beierlein, M ;
Patrick, SL ;
Ho, AM ;
Connors, BW ;
Golomb, D .
JOURNAL OF NEUROSCIENCE, 2002, 22 (10) :4142-4152
[5]   VENTRO-BASAL NUCLEUS OF THALAMUS - POTENTIAL FIELDS SYNAPTIC TRANSMISSION + EXCITABILITY OF BOTH PRESYNAPTIC + POST-SYNAPTIC COMPONENTS [J].
ANDERSEN, P ;
ECCLES, JC ;
BROOKS, CM ;
SEARS, TA .
JOURNAL OF PHYSIOLOGY-LONDON, 1964, 174 (03) :348-&
[6]  
[Anonymous], [No title captured]
[7]  
Aston-Jones G, 2000, PROG BRAIN RES, V126, P165
[8]   ELECTROTONIC COUPLING BETWEEN NEURONES IN RAT MESENCEPHALIC NUCLEUS [J].
BAKER, R ;
LLINAS, R .
JOURNAL OF PHYSIOLOGY-LONDON, 1971, 212 (01) :45-+
[9]   Functional gap junctions in the Schwann cell myelin sheath [J].
Balice-Gordon, RJ ;
Bone, LJ ;
Scherer, SS .
JOURNAL OF CELL BIOLOGY, 1998, 142 (04) :1095-1104
[10]   Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks [J].
Bartos, M ;
Vida, I ;
Frotscher, M ;
Meyer, A ;
Monyer, H ;
Geiger, JRP ;
Jonas, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :13222-13227