Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma and edema volumes

被引：67

作者：

McCarron, MO ^{[1
]}

Hoffmann, KL

DeLong, DM

Gray, L

Saunders, AM

Alberts, MJ

机构：

[1] So Gen Hosp, Inst Neurol Sci, Dept Neurol, Glasgow G51 4TF, Lanark, Scotland

[2] Duke Univ, Med Ctr, Div Neurol, Dept Med,Div Biometry, Durham, NC USA

[3] Duke Univ, Med Ctr, Dept Radiol, Durham, NC USA

来源：

NEUROLOGY | 1999年 / 53卷 / 09期

关键词：

intracerebral hemorrhage; apolipoprotein E; outcome;

D O I：

10.1212/WNL.53.9.2176

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated whether early hematoma or edema volumes could explain the adverse association between APOE epsilon 4 and survival in intracerebral hemorrhage. Among 102 patients, epsilon 4 carriers had a higher mortality rate than non-epsilon 4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm(3) versus 27.1 cm(3), p < 0.001) and edema volumes (37.5 cm(3) versus 17.1 cm(3), p < 0.01), but these were not associated with epsilon 4 after adjusting for race, age, and type of hemorrhage.

引用

页码：2176 / 2179

页数：4

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