Molecular interactions between bacterial symbionts and their hosts

被引:403
作者
Dale, Colin [1 ]
Moran, Nancy A.
机构
[1] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA
[2] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA
基金
美国国家科学基金会;
关键词
D O I
10.1016/j.cell.2006.07.014
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Symbiotic bacteria are important in animal hosts, but have been largely overlooked as they have proved difficult to culture in the laboratory Approaches such as comparative genomics and real-time PCR have provided insights into the molecular mechanisms that underpin symbiont-host interactions. Studies on the heritable symbionts of insects have yielded valuable information about how bacteria infect host cells, avoid immune responses, and manipulate host physiology. Furthermore, some symbionts use many of the same mechanisms as pathogens to infect hosts and evade immune responses. Here we discuss what is currently known about the interactions between bacterial symbionts and their hosts.
引用
收藏
页码:453 / 465
页数:13
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