Low-grade systemic inflammation in patients with amyotrophic lateral sclerosis

被引：83

作者：

Keizman, D. ^{[1
]}

Rogowski, O. ^{[2
]}

Berliner, S. ^{[3
]}

Ish-Shalom, M. ^{[4
]}

Maimon, N. ^{[1
]}

Nefussy, B. ^{[5
]}

Artamonov, I. ^{[5
]}

Drory, V. E. ^{[5
]}

机构：

[1] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Sackler Fac Med, Dept Oncol, IL-64239 Tel Aviv, Israel

[2] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Sackler Fac Med, Dept Internal Med D, IL-64239 Tel Aviv, Israel

[3] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Sackler Fac Med, Dept Internal Med E, IL-64239 Tel Aviv, Israel

[4] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Sackler Fac Med, Dept Internal Med H, IL-64239 Tel Aviv, Israel

[5] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Sackler Fac Med, Dept Neurol, IL-64239 Tel Aviv, Israel

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2009年 / 119卷 / 06期

关键词：

amyotrophic lateral sclerosis; C-reactive protein; motor neuron disease; systemic low-grade inflammation; C-REACTIVE PROTEIN; ATHEROTHROMBOTIC RISK-FACTORS; ALZHEIMERS-DISEASE; LYMPHOCYTE RATIO; ALS; MICROINFLAMMATION; INDIVIDUALS; NEUTROPHIL; DEMENTIA; MARKERS;

D O I：

10.1111/j.1600-0404.2008.01112.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To prospectively determine the intensity of systemic low-grade inflammation in patients with amyotrophic lateral sclerosis (ALS). Patients with ALS and matched healthy controls underwent blood tests for inflammation-sensitive biomarkers: erythrocyte sedimentation rate (ESR), quantitative fibrinogen, wide-range C-reactive protein (wrCRP) concentrations, leukocyte count and neutrophil-to-lymphocyte ratio (NLR). The correlation between these inflammatory biomarkers and disability status of the patients, expressed by the ALS Functional Rating Scale (ALSFRS-R), was evaluated. Eighty patients with ALS and 80 matched controls were included. wrCRP, fibrinogen, ESR and NLR values were significantly elevated in patients compared with controls. There was a significant correlation between the ALSFRS-R score and wrCRP, ESR and fibrinogen levels. This correlation persisted on sequential examinations. A systemic low-grade inflammation was detected in patients with ALS and correlated with their degree of disability. A heightened systemic inflammatory state is apparently associated with a negative prognosis in ALS.

引用

页码：383 / 389

页数：7

共 32 条

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