Direct monitoring of organic reactions on polymeric supports

被引：44

作者：

Carrasco, MR ^{[1
]}

Fitzgerald, MC ^{[1
]}

Oda, Y ^{[1
]}

Kent, SBH ^{[1
]}

机构：

[1] GRYPHON SCI, S SAN FRANCISCO, CA 94080 USA

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(97)01456-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method to use matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) for real-time monitoring of organic reactions on polymeric supports used in solid-phase synthesis is described. The strategy utilizes a synthetic construct that allows for the rapid and convenient direct MALDI analysis of the attached substrates as well as their subsequent chemical cleavage as desired. We have used this strategy to monitor nucleophilic substitutions, palladium-catalyzed coupling reactions, and solid phase peptide synthesis reactions using both Boc- and Fmoc-based chemistries. (C) 1997 Elsevier Science Ltd.

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页码：6331 / 6334

页数：4

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