β-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types

被引：258

作者：

Humeniuk, C

Arlet, G

Gautier, V

Grimont, P

Labia, R

Philippon, A

机构：

[1] CHU Cochin, Serv Bacteriol, F-75679 Paris 14, France

[2] UFR St Antoine, Hop Tenon, Serv Bacteriol, Paris, France

[3] Univ Brest, CNRS, U FRE 2125, Quimper, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 09期

关键词：

D O I：

10.1128/AAC.46.9.3045-3049.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Kluyvera ascorbata produces a beta-lactamase that results in an atypical susceptibility pattern, including low-level resistance to penicillins, cephalothin, and cefuroxime, but this resistance is reversed by clavulanate. Ten nucleotide sequences of the corresponding gene, bla(KLUA), were obtained and were found to have minor variations (96 to 100%). Otherwise, bla(KLUA) was found to be similar (95 to 100%) to some plasmid-encoded CTX-M-type beta-lactamases. Finally, mobilization of bla(KLUA), on a plasmid was found to be mediated probably by a genetic mobile element like ISEcp1.

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页码：3045 / 3049

页数：5

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