Large-scale genome remodelling by the developmentally programmed elimination of germ line sequences in the ciliate Paramecium

被引：48

作者：

Bétermier, M ^{[1
]}

机构：

[1] Ecole Normale Super, Mol Genet Lab, CNRS, UMR 8541, F-75005 Paris, France

来源：

RESEARCH IN MICROBIOLOGY | 2004年 / 155卷 / 05期

关键词：

DNA excision; epigenetic control; double-strand break; IES;

D O I：

10.1016/j.resmic.2004.01.017

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In Paramecium, during the development of the somatic macronucleus, precise excision of thousands of single-copy non-coding sequences is initiated by specific DNA double-strand breaks, while imprecise elimination of germ-line-limited repeated sequences leads to internal deletions or chromosome fragmentation. Recent data point to a role of non-coding RNAs in the epigenetic programming of these rearrangements. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：399 / 408

页数：10

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