Mixed oxo-hydroxy bile acids as actual or potential impurities in ursodeoxycholic acid preparation:: a 1H and 13C NMR study

被引：10

作者：

Bettarello, L ^{[1
]}

Bortolini, O ^{[1
]}

Fantin, G ^{[1
]}

Guerrini, A ^{[1
]}

机构：

[1] Univ Ferrara, Dipartmento Chim, I-44100 Ferrara, Italy

来源：

FARMACO | 2000年 / 55卷 / 01期

关键词：

bile acids; nuclear magnetic resonance; H-1; NMR; C-13;

D O I：

10.1016/S0014-827X(99)00121-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Some distinctive unprecedented H-1 NMR signals and the complete C-13 NMR resonances are assigned for the entire set of mixed oxo-hydroxy bile acid isomers, obtained by selective oxidation of the hydroxy groups at positions (3,7), (3,12) and (3,7,12) of chenodesoxycholic acid, desoxycholic acid and cholic acid, respectively. Partially or totally oxidized products are the major actual or potential impurities formed during the preparation of the pharmaceutically active ursodeoxycholic and chenodeoxycholic acids. (C) 2000 Elsevier Science S.A. AII rights reserved.

引用

页码：51 / 55

页数：5

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