Elucidating mechanisms underlying robustness of morphogen gradients

被引：77

作者：

Eldar, A ^{[1
]}

Shilo, BZ

Barkai, N

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

[2] Weizmann Inst Sci, Dept Phys Complex Syst, IL-76100 Rehovot, Israel

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 04期

基金：

以色列科学基金会;

关键词：

D O I：

10.1016/j.gde.2004.06.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Morphogen gradients play a pivotal role in most phases of developmental patterning. To ensure proper patterning, reproducible gradients are established under diverse environmental conditions and genetic backgrounds. We refer to the capacity to buffer fluctuations in gene dosage or environmental conditions as 'robustness'. By theoretical analysis of mechanisms that facilitate robustness, it is possible to unravel the machinery responsible for generating the spatial distribution of morphogens.

引用

页码：435 / 439

页数：5

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