The effect of culture conditions on the production of erythromycin by Saccharopolyspora erythraea in batch culture

被引：12

作者：

Heydarian, SM ^{[1
]}

Lilly, MD ^{[1
]}

Ison, AP ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,DEPT CHEM & BIOCHEM ENGN,ADV CTR BIOCHEM ENGN,LONDON WC1E 7JE,ENGLAND

来源：

BIOTECHNOLOGY LETTERS | 1996年 / 18卷 / 10期

关键词：

D O I：

10.1007/BF00128589

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Saccharopolyspora erythraea growth is inhibited when grown at a low constant dissolved oxygen tension (DOT) of 10% air saturation. However, the specific erythromycin production is virtually identical to that of a culture where the DOT did not fall below 65%. In addition, at constant DOT (10%) a stirrer speed of 750 rpm in a 7 litre causes mechanical damage to the mycelia in comparison with result at 500 rpm.

引用

页码：1181 / 1186

页数：6

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