Secretion of the galectin family of mammalian carbohydrate-binding proteins

被引:542
作者
Hughes, RC [1 ]
机构
[1] Natl Inst Med Res, London NW7 1AA, England
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 1999年 / 1473卷 / 01期
关键词
galectin; extracellular; secretion;
D O I
10.1016/S0304-4165(99)00177-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Galectins are cytosolic proteins that lack any signal sequence for transport into the endoplasmic reticulum and are not glycosylated, although several galectins contain consensus sites for N-glycosylation, indicating that these proteins do not traverse the ER-Golgi network. However, there is abundant evidence for the extracellular localisation of some galectins at cell surfaces, in the extracellular matrix and in cell secretions consistent with other evidence for extracellular roles of galectins as modulators of cell adhesion and signalling. How then are galectins secreted if not through the classical secretory pathway? Do all galectins share the same secretory pathway? Can a particular galectin utilise more than one secretory pathway? If galectins play important extracellular roles how is their secretion regulated in relation to function? These are still largely unanswered questions but recent studies are beginning to give glimpses into some novel aspects of the secretion of these intriguing proteins. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:172 / 185
页数:14
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