Handedness is mainly associated with an asymmetry of corticospinal excitability and not of transcallosal inhibition

被引:86
作者
De Gennaro, L
Cristiani, R
Bertini, M
Curcio, G
Ferrara, M
Fratello, F
Romei, V
Rossini, PM
机构
[1] Univ Roma La Sapienza, Dipartimento Psicol, I-00185 Rome, Italy
[2] Univ Aquila, Dipartimento Med Interna & Sanita Pubbl, I-67100 Laquila, Italy
[3] Univ Roma 1, Neurol Clin, Rome, Italy
[4] Neurosci Osp Fatebenefratelli, AFaR, Dip Neurosci, Rome, Italy
[5] IRCCS, Ctr S Giovanni Dio Fatebenefratelli, Brescia, Italy
关键词
transcranial magnetic stimulation; handedness; paired-pulse technique; transcallosal inhibition; corpus callosum; corticospinal system; gender;
D O I
10.1016/j.clinph.2004.01.014
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: The study aims to compare transcallosal inhibition (TI), as assessed by the paired-pulse transcranial magnetic stimulation (TMS) technique, in a sample of right-handed subjects (RH) and left-handed subjects (LH). Motor thresholds (MTs) and motor evoked potential (MEP) amplitudes were also measured in the two groups, as an index of corticospinal activity. Methods: Thirty-two normal subjects (16 RH and 16 LH) were recorded with a paired-pulse TMS paradigm (intensity of both pulses = 120% of MT). The inter-stimulus intervals (ISIs) were 2, 4, 6, 8, 10, 12, 14, 16, 18, and 20 ms for both motor cortices, and MEP responses were recorded from the abductor digiti minimi muscles. Results: Both groups showed a clear TI centred around the 12 ms ISI, but no difference was found as a function of handedness or of hemisphere. On the other hand, the two groups differed in terms of corticospinal activity, since the hand motor dominant hemisphere had lower MTs than the non-dominant one in LH, and larger MEP amplitudes for the right hand were found in RH. Conclusions: Results point to a functional asymmetry of the motor cortex on the hand-dominant versus the non-dominant hemisphere, while handedness does not seem associated with functional differences in callosal inhibition, as measured by the inter-hemispheric paired-pulse TMS technique. (C) 2004 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1305 / 1312
页数:8
相关论文
共 43 条
[1]   FIBER COMPOSITION OF THE HUMAN CORPUS-CALLOSUM [J].
ABOITIZ, F ;
SCHEIBEL, AB ;
FISHER, RS ;
ZAIDEL, E .
BRAIN RESEARCH, 1992, 598 (1-2) :143-153
[2]  
CANTELLO R, 1992, NEUROLOGY, V42, P1951
[3]   Organization of ipsilateral excitatory and inhibitory pathways in the human motor cortex [J].
Chen, R ;
Yung, D ;
Li, JY .
JOURNAL OF NEUROPHYSIOLOGY, 2003, 89 (03) :1256-1264
[4]   Intracortical excitatory and inhibitory phenomena to paired transcranial magnetic stimulation in healthy human subjects: differences between the right and left hemisphere [J].
Cicinelli, P ;
Traversa, R ;
Oliveri, M ;
Palmieri, MG ;
Filippi, MM ;
Pasqualetti, P ;
Rossini, PM .
NEUROSCIENCE LETTERS, 2000, 288 (03) :171-174
[5]   Hemispheric asymmetries of cortico-cortical connections in human hand motor areas [J].
Civardi, C ;
Cavalli, A ;
Naldi, P ;
Varrasi, C ;
Cantello, R .
CLINICAL NEUROPHYSIOLOGY, 2000, 111 (04) :624-629
[6]   ANATOMICAL BEHAVIORAL RELATIONSHIPS - CORPUS-CALLOSUM MORPHOMETRY AND HEMISPHERIC-SPECIALIZATION [J].
CLARKE, JM ;
ZAIDEL, E .
BEHAVIOURAL BRAIN RESEARCH, 1994, 64 (1-2) :185-202
[7]   MULTIPLE DIMENSIONS OF HANDEDNESS AND THE HUMAN CORPUS-CALLOSUM [J].
COWELL, PE ;
KERTESZ, A ;
DENENBERG, VH .
NEUROLOGY, 1993, 43 (11) :2353-2357
[8]   COMPARISON OF HUMAN TRANSCALLOSAL RESPONSES EVOKED BY MAGNETIC COIL AND ELECTRICAL-STIMULATION [J].
CRACCO, RQ ;
AMASSIAN, VE ;
MACCABEE, PJ ;
CRACCO, JB .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1989, 74 (06) :417-424
[9]   Reproducibility of callosal effects of transcranial magnetic stimulation (TMS) with interhemispheric paired pulses [J].
De Gennaro, L ;
Ferrara, M ;
Bertini, M ;
Pauri, F ;
Cristiani, R ;
Curcio, G ;
Romei, V ;
Fratello, F ;
Rossini, PM .
NEUROSCIENCE RESEARCH, 2003, 46 (02) :219-227
[10]   Callosal effects of transcranial magnetic stimulation (TMS): the influence of gender and stimulus parameters [J].
De Gennaro, L ;
Bertini, M ;
Pauri, F ;
Cristiani, R ;
Curcio, G ;
Ferrara, M ;
Rossini, PM .
NEUROSCIENCE RESEARCH, 2004, 48 (02) :129-137