Inflammatory bowel disease and celiac disease: Overlaps and differences

被引:73
作者
Pascual, Virginia [1 ]
Dieli-Crimi, Romina [1 ]
Lopez-Palacios, Natalia [2 ]
Bodas, Andres [3 ]
Maria Medrano, Luz [1 ]
Nunez, Concepcion [1 ]
机构
[1] Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Hosp Clin San Carlos, UGC Inmunol, Madrid 28040, Spain
[2] Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Hosp Clin San Carlos, Serv Digest, Madrid 28040, Spain
[3] Hosp Clin San Carlos IdISSC, Inst Invest Sanitaria, Hosp Clin San Carlos, Serv Pediat, Madrid 28040, Spain
关键词
Disease susceptibility; Gene-environment interaction; Immune system; Inflammation; Microbiota; Inflammatory bowel disease; TERM-FOLLOW-UP; CROHNS-DISEASE; MONOCLONAL-ANTIBODY; TRANSGLUTAMINASE ANTIBODIES; PEDIATRIC GASTROENTEROLOGY; MAINTENANCE THERAPY; ULCERATIVE-COLITIS; EARLY-CHILDHOOD; PREVALENCE; ASSOCIATION;
D O I
10.3748/wjg.v20.i17.4846
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
Recent findings demonstrate the common genetic basis for many immune-mediated diseases, and consequently, the partially shared pathogenesis. We collected these findings and reviewed the extension of these overlaps to other disease characteristics. Two autoimmune diseases were selected that also share the specific target organ, the bowel. The etiology and immunopathogenesis of both conditions characterized by chronic intestinal inflammation, inflammatory bowel disease (IBD) and celiac disease (CeD), are not completely understood. Both are complex diseases with genetics and environment contributing to dysregulation of innate and adaptive immune responses, leading to chronic inflammation and disease. CeD constitutes a particular disease because the main environmental and genetic triggers are largely known. IBD comprises two main clinical forms, Crohn's disease and ulcerative colitis, which most likely involve a complex interplay between some components of the commensal microbiota and other environmental factors in their origin. These multifactorial diseases encompass a broad spectrum of clinical phenotypes and ages of onset, although the clinical presentation often differs depending on childhood or adult onset, with greater heterogeneity commonly observed in adults. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
引用
收藏
页码:4846 / 4856
页数:11
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