The Insulin Receptor Talks to Glucagon?

被引：16

作者：

Gromada, Jesper ^{[1
]}

Duttaroy, Alokesh ^{[1
]}

Rorsman, Patrik ^{[2
]}

机构：

[1] Novartis Inst BioMed Res, Cambridge, MA 02139 USA

[2] Univ Oxford, OCDEM, Churchill Hosp, Oxford OX3 7LJ, England

来源：

CELL METABOLISM | 2009年 / 9卷 / 04期

关键词：

ALPHA-CELLS; BETA-CELL; ATP; SECRETION; RELEASE; CHANNELS; ISLETS;

D O I：

10.1016/j.cmet.2009.03.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Type 2 diabetes (T2DM) is not only a disorder of impaired insulin secretion but also glucagon oversecretion. However, the link between the two remains unclear. Is it possible that the latter is a consequence of the former? In this issue, Kawamori et al. (2009) have addressed this question by generating alpha cell-specific insulin receptor knockout mice.

引用

收藏

页码：303 / 305

页数：3

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