Imaging P-glycoprotein at the human blood-brain barrier

被引：3

作者：

Franssen, Eric J. F. ^{[1
]}

Luurtsema, Gert

Lammertsma, Adriaan A.

机构：

[1] Onze Lieve Vrouw Hosp, Dept Pharm & Pharmacol, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Ctr Med, Dept Nucl Med & PET Res, Amsterdam, Netherlands

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2006年 / 80卷 / 03期

关键词：

D O I：

10.1016/j.clpt.2006.06.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：302 / 303

页数：2

共 8 条

[1] Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET [J].

Bart, J ;

Willemsen, ATM ;

Groen, HJM ;

van der Graaf, WTA ;

Wegman, TD ;

Vaalburg, W ;

de Vries, EGE ;

Hendrikse, NH .

NEUROIMAGE, 2003, 20 (03) :1775-1782

[2]

Hendrikse NH, 1999, CANCER RES, V59, P2411

[3] Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography [J].

Hendrikse, NH ;

Schinkel, AH ;

De Vries, EGE ;

Fluks, E ;

Van der Graaf, WTA ;

Willemsen, ATM ;

Vaalburg, W ;

Franssen, EJF .

BRITISH JOURNAL OF PHARMACOLOGY, 1998, 124 (07) :1413-1418

[4]

LUBBERINK M, 2006, J CEREB BLOOD FLOW M

[5] Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier:: kinetics and metabolism in the rat [J].

Luurtsema, G ;

Molthoff, CFM ;

Schuit, RC ;

Windhorst, AD ;

Lammertsma, AA ;

Franssen, EJF .

NUCLEAR MEDICINE AND BIOLOGY, 2005, 32 (01) :87-93

[6] (R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function:: in vitro and in vivo evaluation [J].

Luurtsema, G ;

Molthoff, CFM ;

Windhorst, AD ;

Smit, JW ;

Keizer, H ;

Boellaard, R ;

Lammertsma, AA ;

Franssen, EJF .

NUCLEAR MEDICINE AND BIOLOGY, 2003, 30 (07) :747-751

[7] Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography [J].

Sasongko, L ;

Link, JM ;

Muzi, M ;

Mankoff, DA ;

Yang, XD ;

Collier, AC ;

Shoner, SC ;

Unadkat, JD .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2005, 77 (06) :503-514

[8] Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of ( R )-[11C]verapamil and positron emission tomography [J].

Toornvliet, Rolf ;

van Berckel, Bart N. M. ;

Luurtsema, Gert ;

Lubberink, Mark ;

Geldof, Albert A. ;

Bosch, Tessa M. ;

Oerlemans, Ruud ;

Lammertsma, Adriaan A. ;

Franssen, Eric J. F. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2006, 79 (06) :540-548

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