A common repertoire of autoantibodies is shared by cancer and autoimmune disease patients: Inflammation in their induction and impact on tumor growth

被引：79

作者：

Bei, R. ^{[1
]}

Masuelli, L. ^{[2
]}

Palumbo, C. ^{[1
]}

Modesti, M. ^{[3
]}

Modesti, A. ^{[1
]}

机构：

[1] Univ Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy

[2] Univ Sapienza, Dept Expt Med, Rome, Italy

[3] Univ Sapienza, Dept Surg Sci, Rome, Italy

来源：

CANCER LETTERS | 2009年 / 281卷 / 01期

关键词：

Tumor antigens; Anti-cancer immunity; Immune tolerance; Autoantibodies; Inflammation; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANTI-DNA ANTIBODIES; B-CELL EPITOPE; RIBOSOMAL-P-PROTEINS; OF-THE-LITERATURE; LUNG-CANCER; P53; AUTOANTIBODIES; IMMUNE-RESPONSE; SELF-ANTIGENS; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1016/j.canlet.2008.11.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The repertoire of autoantibodies found in cancer patients partly overlaps with that typical of patients with autoimmune diseases. Beside the biochemical and immunological properties of the target antigens and their altered expression in tumor tissues, the intratumoral inflammatory context can play a key role in the induction of autoimmune disease-associated autoantibodies in cancer patients. Furthermore, the impact of such antibodies on cancer growth and progression can be deeply influenced by the interplay with inflammation. The characterization of the spontaneous humoral responses occurring in cancer patients, of the mechanisms that trigger and sustain the autoantibody response and of the biological effects of such autoantibodies may help the rational design of anti-cancer immunotherapeutic protocols. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：8 / 23

页数：16

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