Plasma intestinal fatty acid binding protein (I-FABP) concentrations increase-following intestinal ischemia in pigs

被引：92

作者：

Niewold, TA ^{[1
]}

Meinen, M ^{[1
]}

van der Meulen, J ^{[1
]}

机构：

[1] Res Grp Anim Physiol & Hlth, Div Anim Resources Dev, Anim Sci Grp, NL-8200 AB Lelystad, Netherlands

来源：

RESEARCH IN VETERINARY SCIENCE | 2004年 / 77卷 / 01期

关键词：

pig; intestinal ischemia; fatty acid binding protein;

D O I：

10.1016/j.rvsc.2004.02.006

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Intestinal fatty acid binding protein (I-FABP) is an intracellular epithelial protein in the intestinal mucosa of many animals. IFABP appears in the circulation following epithelial damage, and in humans, is proven to be a parameter for damage to the mucosa. In this paper, an ELISA test designed for human I-FABP analysis was used to assay pig blood samples. The test recognized I-FABP cloned from pig small intestine and expressed in Escherichia coli. Furthermore, in our experimental model of (low flow) intestinal ischemia and reperfusion a significant rise in plasma I-FABP concentrations 15-30 min after clamping of the mesenteric artery was demonstrated. This is the first report that in pigs circulating I-FABP is a useful marker for (mild) intestinal injury, and could possibly be used to monitor (intestinal) health in clinical practice. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：89 / 91

页数：3

共 20 条

[1] Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia? [J].