Cholesterol and APOE genotype interact to influence Alzheimer disease progression

被引：98

作者：

Evans, RM

Hui, S

Perkins, A

Lahiri, DK

Poirier, J

Farlow, MR

机构：

[1] Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN USA

[3] Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA

[4] Indiana Univ, Sch Med, Regenstrief Inst Hlth Care, Indianapolis, IN 46202 USA

[5] McGill Ctr Studies Aging, Montreal, PQ, Canada

来源：

NEUROLOGY | 2004年 / 62卷 / 10期

关键词：

D O I：

10.1212/01.WNL.0000125323.15458.3F

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this retrospective analysis of 443 Alzheimer disease ( AD) patients from a 30-week tacrine trial, change in Alzheimer's Disease Assessment Scale score from baseline to final value was significantly associated with a total serum cholesterol/ APOE genotype interaction. Disease progression in the no-APOE epsilon4 allele/high-cholesterol subgroup was greater than in the normal-cholesterol subgroups with or without epsilon4. Cholesterol levels and APOE genotype may interact to affect AD progression. The results are consistent with preclinical data on cholesterol's effects in AD.

引用

页码：1869 / 1871

页数：3

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