Heparin-induced thrombocytopenia

被引:339
作者
Arepally, Gowthami M.
Ortel, Thomas L.
机构
[1] Duke Univ, Med Ctr, Dept Med, Div Hematol, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
关键词
D O I
10.1056/NEJMcp052967
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 63-year-old man with coronary artery disease who has recently undergone bypass surgery presents with dyspnea. Findings on physical examination are unremarkable. Laboratory testing reveals a platelet count of 86,000 per cubic millimeter, as compared with 225,000 per cubic millimeter at the time of discharge nine days earlier. The results of chest radiography are unremarkable; spiral computed tomography of the chest shows a pulmonary embolism. Heparin-induced thrombocytopenia is suspected. What diagnostic studies are warranted, and how should this patient be treated? Copyright © 2006 Massachusetts Medical Society.
引用
收藏
页码:809 / 817
页数:9
相关论文
共 51 条
[1]  
AMIRAL J, 1992, THROMB HAEMOSTASIS, V68, P95
[2]   Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia [J].
Amiral, J ;
MarfaingKoka, A ;
Wolf, M ;
Alessi, MC ;
Tardy, B ;
BoyerNeumann, C ;
Vissac, AM ;
Fressinaud, E ;
Poncz, M ;
Meyer, D .
BLOOD, 1996, 88 (02) :410-416
[3]  
[Anonymous], CHEST
[4]   Prospective randomised open-label comparison of danaparoid with dextran 70 in the treatment of heparin-induced thrombocytopaenia with thrombosis - A clinical outcome study [J].
Chong, BH ;
Gallus, AS ;
Cade, JF ;
Magnani, H ;
Manoharan, A ;
Oldmeadow, M ;
Arthur, C ;
Rickard, K ;
Gallo, J ;
Lloyd, J ;
Seshadri, P ;
Chesterman, CN .
THROMBOSIS AND HAEMOSTASIS, 2001, 86 (05) :1170-1175
[5]   Risk factors for thrombosis in patients with immune mediated heparin-induced thrombocytopenia [J].
Fabris, F ;
Luzzatto, G ;
Soini, B ;
Ramon, R ;
Scandellari, R ;
Randi, ML ;
Girolami, A .
JOURNAL OF INTERNAL MEDICINE, 2002, 252 (02) :149-154
[6]   A comparison of danaparoid and lepirudin in heparin-induced thrombocytopenia [J].
Farner, B ;
Eichler, P ;
Kroll, H ;
Greinacher, A .
THROMBOSIS AND HAEMOSTASIS, 2001, 85 (06) :950-957
[7]   Heparin-induced thrombocytopenia is rare in pregnancy [J].
Fausett, MB ;
Vogtlander, M ;
Lee, RM ;
Esplin, MS ;
Branch, DW ;
Rodgers, GM ;
Silver, RM .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2001, 185 (01) :148-152
[8]   The incidence of heparin-induced thrombocytopenia in hospitalized medical patients treated with subcutaneous unfractionated heparin: a prospective cohort study [J].
Girolami, B ;
Prandoni, P ;
Stefani, PM ;
Tanduo, C ;
Sabbion, P ;
Eichler, P ;
Ramon, R ;
Baggio, G ;
Fabris, F ;
Girolami, A .
BLOOD, 2003, 101 (08) :2955-2959
[9]   Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy [J].
Greer, IA ;
Nelson-Piercy, C .
BLOOD, 2005, 106 (02) :401-407
[10]   Clinical features of heparin-induced thrombocytopenia including risk factors for thrombosis [J].
Greinacher, A ;
Farner, B ;
Kroll, H ;
Kohlmann, T ;
Warkentin, TE ;
Eichler, P .
THROMBOSIS AND HAEMOSTASIS, 2005, 94 (01) :132-135