Determination of ligustilide in rat brain after nasal administration of essential oil from Rhizoma Chuanxiong

被引：35

作者：

Guo, Jianming ^{[1
]}

Duan, Jin-ao ^{[1
]}

Shang, Er-xin ^{[1
]}

Tang, Yuping ^{[1
]}

Qian, Dawei ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab TCM Formulae Res, Nanjing 210046, Peoples R China

来源：

FITOTERAPIA | 2009年 / 80卷 / 03期

关键词：

Ligustilide; Nasal administration; HPLC-UV; GAS CHROMATOGRAPHY/MASS SPECTROMETRY; BIOACTIVE COMPONENTS; CEREBROSPINAL-FLUID; BUTYLIDENEPHTHALIDE; BLOOD; CONSTITUENTS; DECOCTION; BEHAVIOR; PLASMA; CAVITY;

D O I：

10.1016/j.fitote.2009.01.003

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A simple and sensitive HPLC-UV method was developed to determine ligustilide in rat brain samples after nasal administration. The lower limit of quantification (LLOQ) was 245 ng/ml for ligustilide. The calibration curve was linear over a concentration range of 245-4900 ng/ml. Brain samples were obtained at regular time intervals after nasal administration of ligustilide (45 mg/kg). Ligustilide could be detected in rat brain only after 5 min of nasal administration; which showed that ligustilide may have a rapid onset of action. This result illustrates that intranasal administration of ligustilide may act as a promising alternative to conventional routes of administration. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：168 / 172

页数：5

共 25 条

[1]

Ligustilide induces vasodilatation via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release [J].