Single molecule Raman scattering

被引：129

作者：

Kneipp, Katrin ^{[1
]}

Kneipp, Harald ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Harvard Mit Div Hlth Sci & Technol, Wellman Ctr Photomed, Boston, MA 02114 USA

来源：

APPLIED SPECTROSCOPY | 2006年 / 60卷 / 12期

关键词：

D O I：

10.1366/000370206779321418

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The use of Surface-enhanced Raman Scattering (SERS), which uses near-infrared (NIR) excitation light, non-resonant to the electronic transitions of the target molecule is discussed. The applications range from the use of Raman spectroscopic characterization of specific DNA fragments to structurally sensitive detection of single bases without the use of fluorescent or radioactive tags. The effective nonresonant SERS cross-sections of good laser dyes or many even exceed these numbers. The single molecule SERS is primarily a phenomenon associated with strongly enhanced and geometrically confined local optical fields. The SERS spectroscopy will provide some advantages over fluorescence and is the most suitable method for detecting single molecule.

引用

页码：322A / 334A

页数：13

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