Unraveling the transcriptional network controlling ES cell pluripotency

被引：31

作者：

Rao, Sridhar

Orkin, Stuart H. ^{[1
]}

机构：

[1] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Harvard Univ, Stem Cell Inst, Boston, MA 02115 USA

[4] Childrens Hosp, Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

GENOME BIOLOGY | 2006年 / 7卷 / 08期

关键词：

D O I：

10.1186/gb-2006-7-8-230

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Embryonic stem cells (ES cells) are powerful tools for genetic engineering and hold significant potential for regenerative medicine. Recent work provides new insights into ES cell pluripotency and delineates separate transcriptional pathways in ES cells for maintenance of the undifferentiated state and for self-renewal.

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