Oligoclonal expansions of mucosal T cells in Crohn's disease predominate in NKG2D-expressing CD4 T cells

被引：30

作者：

Camus, M. ^{[1
,2
]}

Esses, S. ^{[3
]}

Pariente, B. ^{[1
,4
]}

Le Bourhis, L. ^{[1
,2
]}

Douay, C. ^{[2
,5
]}

Chardiny, V. ^{[1
,2
]}

Mocan, I. ^{[1
,2
]}

Benlagha, K. ^{[2
,5
]}

Clave, E. ^{[2
,5
]}

Toubert, A. ^{[2
,5
]}

Mayer, L. ^{[3
]}

Allez, M. ^{[1
,2
,4
,5
]}

机构：

[1] AVENIR INSERM, Paris, France

[2] Hop St Louis, Inst Univ Hematol, INSERM U940, Paris, France

[3] Mt Sinai Sch Med, Immunobiol Ctr, New York, NY USA

[4] Hop St Louis, AP HP, Dept Gastroenterol, Paris, France

[5] Univ Paris Diderot, Paris, France

来源：

MUCOSAL IMMUNOLOGY | 2014年 / 7卷 / 02期

关键词：

INFLAMMATORY-BOWEL-DISEASE; INTESTINAL EPITHELIAL-CELLS; GENOME-WIDE ASSOCIATION; GENETIC-BASIS; RECEPTOR; NKG2D; REPERTOIRE; RECURRENCE; LIGANDS; PEPTIDE;

D O I：

10.1038/mi.2013.51

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Crohn's disease (CD) is an inflammatory pathology of the mucosal intestine that results from uncontrolled immune response towards commensal microbes. Clonal expansions of T cells have been found in patients with CD suggesting an antigen-specific stimulation of pathogenic Tcells. Here we show, using T-cell receptor repertoire analysis by real-time PCR, that oligoclonal expansions are found in both CD8+ and CD4+ T cells in the blood and intestinal mucosa of CD patients. The majority of CD4+ T-cell-expanded clones are CD4+NKG2D+ T cells. These clonal expansions were found in both inflamed and neighboring healthy tissue and were persisting during the course of the disease. The presence of these CD4+NKG2D+ T-cell clones at the macroscopically normal edge of the surgical resection might be predictive of inflammation relapse post surgery.

引用

页码：325 / 334

页数：10

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