Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology

被引：511

作者：

Ashbee, H. Ruth ^{[1
]}

Barnes, Rosemary A. ^{[2
]}

Johnson, Elizabeth M. ^{[3
]}

Richardson, Malcolm D. ^{[4
,5
]}

Gorton, Rebecca ^{[6
]}

Hope, William W. ^{[7
]}

机构：

[1] Leeds Teaching Hosp NHS Trust, Dept Microbiol, Mycol Reference Ctr, Leeds LS1 3EX, W Yorkshire, England

[2] Cardiff Univ, Dept Med Microbiol & Infect Dis, Inst Infect & Immun, Sch Med, Cardiff CF14 4XN, S Glam, Wales

[3] South West Lab, Publ Hlth England Mycol Reference Lab, Bristol BS2 8EL, Avon, England

[4] Univ S Manchester Hosp, Mycol Reference Ctr, Manchester M23 9LT, Lancs, England

[5] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester M23 9LT, Lancs, England

[6] Royal Free Hosp, Dept Microbiol, London NW3 2QG, England

[7] Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool L69 3BX, Merseyside, England

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2014年 / 69卷 / 05期

基金：

美国国家卫生研究院;

关键词：

triazoles; fungal pathogens; fungal diseases; INVASIVE FUNGAL-INFECTIONS; PERFORMANCE LIQUID-CHROMATOGRAPHY; STEM-CELL TRANSPLANTATION; POSACONAZOLE PLASMA-CONCENTRATIONS; SERUM ITRACONAZOLE CONCENTRATIONS; HYDROXYPROPYL-BETA-CYCLODEXTRIN; GUINEA-PIG MODEL; TO-ORAL SWITCH; IN-VITRO MODEL; ASPERGILLUS-FUMIGATUS;

D O I：

10.1093/jac/dkt508

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The burden of human disease related to medically important fungal pathogens is substantial. An improved understanding of antifungal pharmacology and antifungal pharmacokineticspharmacodynamics has resulted in therapeutic drug monitoring (TDM) becoming a valuable adjunct to the routine administration of some antifungal agents. TDM may increase the probability of a successful outcome, prevent drug-related toxicity and potentially prevent the emergence of antifungal drug resistance. Much of the evidence that supports TDM is circumstantial. This document reviews the available literature and provides a series of recommendations for TDM of antifungal agents.

引用

页码：1162 / 1176

页数：15

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