Quantification of alpha(2A) and alpha(2C) adrenoceptors in the rat striatum and in different regions of the spinal cord

被引：27

作者：

Uhlen, S ^{[1
]}

Lindblom, J ^{[1
]}

Tiger, G ^{[1
]}

Wikberg, JES ^{[1
]}

机构：

[1] UMEA UNIV,DEPT PHARMACOL,S-90187 UMEA,SWEDEN

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1997年 / 160卷 / 04期

关键词：

adrenoceptor; alpha(2A); alpha(2C); cervical; subtypes; rat; spinal cord; striatum; H-3]-MK912;

D O I：

10.1046/j.1365-201X.1997.00175.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The alpha(2C)-adrenoceptor preferring radioligand [H-3]-MK912 was used for labelling alpha(2A)- and alpha(2C)- adrenoceptors in the rat striatum, in the cervical, thoracic and lumbar parts of the spinal cord, and in the dorsal and ventral halves of the spinal cord, in addition, guanfacine was used as a tool to delineate the zeta(2A)- and alpha(2C)-adrenoceptors. In the striatum the sites were 72% alpha(2A)- and 28% alpha(2C)-adrenoceptors, while in all regions of the spinal cord the proportions of the sites were about 96% alpha(2A)- and 4% alpha(2C)-adrenoceptors. A multi-curve experimental design and computer analysis was used in order to enable the accurate quantification of the alpha(2A)- and alpha(2C)-adrenoceptors in the striatum and spinal cord.

引用

页码：407 / 412

页数：6

共 23 条

[1]

ARMAH BI, 1988, N-S ARCH PHARMACOL S, V338, pR55

[2]

Arnsten AFT, 1996, ARCH GEN PSYCHIAT, V53, P448

[3]

BYLUND DB, 1994, PHARMACOL REV, V46, P121

[4] alpha(2)-adrenoceptors take centre stage at Nashville meeting [J].