Latent fluorophores based on a Mannich cyclisation trigger

被引：14

作者：

Clave, Guillaume

Bernardin, Aude

Massonneau, Marc

Renard, Pierre-Yves

Romieu, Anthony

机构：

[1] INSA Rouen, CNRS, UMR 6014, Equipe Chim Bioorgan,IRCOF,LHO, F-76131 Mont St Aignan, France

[2] Univ Rouen, F-76131 Mont St Aignan, France

[3] ESIGELEC, QUIDD, F-76801 St Etienne, France

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 35期

关键词：

pro-fluorophore; fluorescent probe; penicillin G acylase;

D O I：

10.1016/j.tetlet.2006.06.138

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the synthesis of a strongly blue-fluorescent pyrazino-benz[e]indole derivative, and its utility for enzyme sensing in biological assays through an original Mannich cyclisation triggered fluorescence unveiling. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：6229 / 6233

页数：5

相关论文

共 29 条

[1]

[Anonymous], [No title captured]

[2] RULES FOR RING-CLOSURE [J].

BALDWIN, JE .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1976, (18) :734-736

[3] Latent fluorophore based on the trimethyl lock [J].

Chandran, SS ;

Dickson, KA ;

Raines, RT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (06) :1652-1653

[4] A selective, cell-permeable optical probe for hydrogen peroxide in living cells [J].

Chang, MCY ;

Pralle, A ;

Isacoff, EY ;

Chang, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (47) :15392-15393

[5] Progress in spectroscopic probes with cleavable active bonds [J].

Chen, XQ ;

Sun, M ;

Ma, HM .

CURRENT ORGANIC CHEMISTRY, 2006, 10 (04) :477-489

[6] Role of excited state intramolecular charge transfer in the photophysical properties of norfloxacin and its derivatives [J].

Cuquerella, MC ;

Miranda, MA ;

Bosca, F .

JOURNAL OF PHYSICAL CHEMISTRY A, 2006, 110 (08) :2607-2612

[7]

DEGUTIS J, 1987, KHIM GETEROTSIKL+, P227

[8] Recent advances in enzyme assays [J].

Goddard, JP ;

Reymond, JL .

TRENDS IN BIOTECHNOLOGY, 2004, 22 (07) :363-370

[9] Enzyme assays for high-throughput screening [J].

Goddard, JP ;

Reymond, JL .

CURRENT OPINION IN BIOTECHNOLOGY, 2004, 15 (04) :314-322

[10] Development of novel assays for proteolytic enzymes using rhodarnine-based fluorogenic substrates [J].

Grant, SK ;

Sklar, JG ;

Cummings, RT .

JOURNAL OF BIOMOLECULAR SCREENING, 2002, 7 (06) :531-540