Association of monoamine oxidase A gene polymorphism with Alzheimer's disease and Lewy body variant

被引：45

作者：

Takehashi, M

Tanaka, S ^{[1
]}

Masliah, E

Ueda, K

机构：

[1] Kyoto Univ, Lab Mol Clin Chem, Inst Chem Res, Uji, Kyoto 6110011, Japan

[2] Univ Calif San Diego, Dept Neurosci, Sch Med, La Jolla, CA 92093 USA

来源：

NEUROSCIENCE LETTERS | 2002年 / 327卷 / 02期

关键词：

monoamine oxidase A; monoamine oxidase B; Parkinson's disease; Alzheimer's disease; Lewy body variant of Alzheimer's disease; (GT)n dinucleotide repeat; polymorphism; allelic association study;

D O I：

10.1016/S0304-3940(02)00258-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The association between (GT)n dinucleotide repeats in monoamine oxidase gene loci, monoamine oxidase A (MAOA) and B (MAOB), and Parkinson's disease (PD), Alzheimer's disease (AD), and Lewy body variant (LBV) of AD were determined. MAOA-GT polymorphisms were significantly associated with pure AD and LBV. MAOA-GT allele 113 was excessively represented in pure AD and LBV compared with controls. Furthermore, the frequency of females homozygous for MAOA-GT allele 113 was higher in pure AD and LBV than controls by 2.79- and 2.77-fold, respectively. In contrast, there was no association between MAOA-GT or MAOB-GT polymorphisms and PD. These results suggest that polymorphisms within the MAOA gene may have implication in AD pathology shared by pure AD and LBV. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：79 / 82

页数：4

共 18 条

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