Protective effect of selenium-polysaccharides from the mycelia of Coprinus comatus on alloxan-induced oxidative stress in mice

被引：165

作者：

Yu, Jie ^{[1
]}

Cui, Peng-Ju ^{[1
]}

Zeng, Wei-Ling ^{[1
]}

Xie, Xiao-Ling ^{[1
]}

Liang, Wei-Jin ^{[1
]}

Lin, Geng-Biao ^{[1
]}

Zeng, Liang ^{[1
]}

机构：

[1] Shantou Univ, Dept Biol, Shantou 515063, Guangdong, Peoples R China

来源：

FOOD CHEMISTRY | 2009年 / 117卷 / 01期

关键词：

Coprinus comatus; Polysaccharide; Selenium; Alloxan-induced diabetic mice; Oxidative stress; Antioxidant; FREE-RADICALS; STREPTOZOTOCIN; SUPEROXIDE; INSULIN; GLUTATHIONE; SELENATE; CELLS; LIVER;

D O I：

10.1016/j.foodchem.2009.03.073

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

We investigated the effect of selenium-polysaccharide (SPS) isolated from selenium-enriched mycelia of Coprinus comatus on hypoglycaemic, hypolipidemic and antioxidant activities in diabetic mice. Compared with untreated diabetic mice, the administration of SPS for 20 days caused a significant decrease (p < 0.05) in blood glucose levels. Simultaneously, the alteration in lipid metabolism was partially attenuated as evidenced by decreased serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL) levels and by increased high-density lipoprotein cholesterol (HDL) concentration in diabetic mice (p < 0.05). In addition, the SPS caused a significant decrease (p < 0.05) in the level of malondialdehyde (MDA) and a significant increase (p < 0.05) in the activities of enzymic antioxidants and the levels of non-enzymic antioxidants in liver and kidney of diabetic mice. Furthermore, the effects of SPS was more potent than that of polysaccharide (PS) from mycelia of C. comatus at the same dose. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：42 / 47

页数：6

共 30 条

[1]

Oral selenate improves glucose homeostasis and partly reverses abnormal expression of liver glycolytic and gluconeogenic enzymes in diabetic rats [J].